Unravelling the paradoxical effects of ganglia ablation.

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

Insulin Within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats

Broad nervous circuits originate from the hypothalamic arcuate nucleus project to many parts of the brain which are related to pain perception. Insulin receptors have been found in the arcuate nucleus. Since nociception may be affected in type 1 diabetes, the present study aimed to investigate the intra-arcuate nucleus insulin role in pain perception in STZ-induced diabetic and healthy rats. Fo...

New model of computer analysis for assessment of the effects of lesions induced by direct voltage current in isolated AV-node of rabbit

Introduction: The ablation technique is one of the important therapeutic interventions for treatment of AV Nodal tachyarrhythmia. Different animal models have been developed to study the effects of ablation on the functional interanodal structure. The aim of the present study was to develop a new model of computer analysis to produce lesions by using direct voltage in isolated perfused rabbi...

Basal Gangha Glucose Uthzation after Precentral Ablation in the Monkey

In the macaque monkey, unilateral ablation of areas 4 and 6 of Brodmann results initially i n a significant decrease of glucose metabolic activity in the ipsilateral caudate nucleus, putamen, globus pallidus, substantia nigra, and subthalamic nucleus. The contralateral hemisphere shows nonsignificant bu t consistently decreased activity in the caudate nucleus, putamen, and globus pallidus. Cere...

Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia.

BACKGROUND Pulmonary vein (PV) -encircling radiofrequency ablation frequently is effective in vagal atrial fibrillation (AF), and there is evidence that PVs may be particularly prone to cholinergically induced arrhythmia mechanisms. However, PV ablation procedures also can affect intracardiac autonomic ganglia. The present study examined the relative role of PVs versus peri-PV autonomic ganglia...